benzhydrocodone/acetaminophen, doxylamine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
doxylamine, calcium/magnesium/potassium/sodium oxybates.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
fentanyl, doxylamine.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.
fentanyl intranasal, doxylamine.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.
fentanyl transdermal, doxylamine.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.
fentanyl transmucosal, doxylamine.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.
hydrocodone, doxylamine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
isocarboxazid increases effects of doxylamine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .
lemborexant, doxylamine.Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Use of lemborexant with other drugs to treat insomnia is not recommended.
methylene blue and doxylamine both increase serotonin levels. Avoid or Use Alternate Drug. If drug combination must be administered, monitor for evidence of serotonergic or opioid-related toxicities
doxylamine, metoclopramide intranasal.Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.
doxylamine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychom*otor performance and cause daytime impairment.
selinexor, doxylamine. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.
doxylamine, sodium oxybate.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
sufentanil SL, doxylamine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
tranylcypromine increases effects of doxylamine by Other (see comment). Avoid or Use Alternate Drug. Comment: Tranylcypromine should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .
valerian and doxylamine both increase sedation. Avoid or Use Alternate Drug.
doxylamine, zuranolone.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration of zuranolone with other CNS depressants may increase impairment of psychom*otor performance or CNS depressant effects. If unavoidable, consider dose reduction. .
doxylamine increases effects of abobotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Drugs with anticholinergic effects may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
acrivastine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and alfentanil both increase sedation. Use Caution/Monitor.
alprazolam and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
amisulpride and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and amitriptyline both increase sedation. Use Caution/Monitor.
amobarbital and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and amoxapine both increase sedation. Use Caution/Monitor.
doxylamine increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
doxylamine and apomorphine both increase sedation. Use Caution/Monitor.
doxylamine and aripiprazole both increase sedation. Use Caution/Monitor.
asenapine and doxylamine both increase sedation. Use Caution/Monitor.
asenapine transdermal and doxylamine both increase sedation. Use Caution/Monitor.
avapritinib and doxylamine both increase sedation. Use Caution/Monitor.
azelastine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and baclofen both increase sedation. Use Caution/Monitor.
doxylamine and belladonna and opium both increase sedation. Use Caution/Monitor.
doxylamine and benperidol both increase sedation. Use Caution/Monitor.
benzhydrocodone/acetaminophen and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
brexanolone, doxylamine.Either increases toxicity of the other by sedation. Use Caution/Monitor.
brexpiprazole and doxylamine both increase sedation. Use Caution/Monitor.
brimonidine and doxylamine both increase sedation. Use Caution/Monitor.
brivaracetam and doxylamine both increase sedation. Use Caution/Monitor.
brompheniramine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and buprenorphine both increase sedation. Use Caution/Monitor.
doxylamine and buprenorphine buccal both increase sedation. Use Caution/Monitor.
buprenorphine subdermal implant and doxylamine both increase sedation. Use Caution/Monitor.
buprenorphine transdermal and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.buprenorphine, long-acting injection and doxylamine both increase sedation. Use Caution/Monitor.
butabarbital and doxylamine both increase sedation. Use Caution/Monitor.
butalbital and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and butorphanol both increase sedation. Use Caution/Monitor.
carbinoxamine and doxylamine both increase sedation. Use Caution/Monitor.
cariprazine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and carisoprodol both increase sedation. Use Caution/Monitor.
cenobamate, doxylamine.Either increases effects of the other by sedation. Use Caution/Monitor.
chloral hydrate and doxylamine both increase sedation. Use Caution/Monitor.
chlordiazepoxide and doxylamine both increase sedation. Use Caution/Monitor.
chlorpheniramine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and chlorpromazine both increase sedation. Use Caution/Monitor.
doxylamine and chlorzoxazone both increase sedation. Use Caution/Monitor.
cinnarizine and doxylamine both increase sedation. Use Caution/Monitor.
clemastine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).
doxylamine and clomipramine both increase sedation. Use Caution/Monitor.
clonazepam and doxylamine both increase sedation. Use Caution/Monitor.
clonidine, doxylamine.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.
clorazepate and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and clozapine both increase sedation. Use Caution/Monitor.
doxylamine and codeine both increase sedation. Use Caution/Monitor.
cyclizine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and cyclobenzaprine both increase sedation. Use Caution/Monitor.
cyproheptadine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and dantrolene both increase sedation. Use Caution/Monitor.
doxylamine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychom*otor performance and cause daytime impairment.
doxylamine increases effects of daxibotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Drugs with anticholinergic effects may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
doxylamine and desipramine both increase sedation. Use Caution/Monitor.
desloratadine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and deutetrabenazine both increase sedation. Use Caution/Monitor.
dexchlorpheniramine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
dexmedetomidine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and dextromoramide both increase sedation. Use Caution/Monitor.
doxylamine and diamorphine both increase sedation. Use Caution/Monitor.
diazepam and doxylamine both increase sedation. Use Caution/Monitor.
diazepam buccal and doxylamine both increase sedation. Use Caution/Monitor.diazepam buccal, doxylamine.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.
diazepam intranasal, doxylamine.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diazepam intranasal and doxylamine both increase sedation. Use Caution/Monitor.
difelikefalin and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and difenoxin hcl both increase sedation. Use Caution/Monitor.
dimenhydrinate and doxylamine both increase sedation. Use Caution/Monitor.
diphenhydramine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.
doxylamine and dipipanone both increase sedation. Use Caution/Monitor.
doxylamine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
doxylamine and dosulepin both increase sedation. Use Caution/Monitor.
doxylamine and doxepin both increase sedation. Use Caution/Monitor.
doxylamine and droperidol both increase sedation. Use Caution/Monitor.
esketamine intranasal, doxylamine.Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.
estazolam and doxylamine both increase sedation. Use Caution/Monitor.
eszopiclone and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and ethanol both increase sedation. Use Caution/Monitor.
etomidate and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fentanyl and doxylamine both increase sedation. Use Caution/Monitor.
fentanyl intranasal and doxylamine both increase sedation. Use Caution/Monitor.
fentanyl iontophoretic transdermal system and doxylamine both increase sedation. Use Caution/Monitor.
fentanyl transdermal and doxylamine both increase sedation. Use Caution/Monitor.
fentanyl transmucosal and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.
doxylamine and fluphenazine both increase sedation. Use Caution/Monitor.
flurazepam and doxylamine both increase sedation. Use Caution/Monitor.
gabapentin, doxylamine.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
gabapentin enacarbil, doxylamine.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
doxylamine and ganaxolone both increase sedation. Use Caution/Monitor.
gotu kola increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
doxylamine and haloperidol both increase sedation. Use Caution/Monitor.
hawthorn increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
hops increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
doxylamine decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Antihistamines, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect. .
doxylamine and hydromorphone both increase sedation. Use Caution/Monitor.
hydroxyzine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and iloperidone both increase sedation. Use Caution/Monitor.
doxylamine and imipramine both increase sedation. Use Caution/Monitor.
doxylamine increases effects of incobotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Drugs with anticholinergic effects may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
kava increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
ketamine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
lasmiditan, doxylamine.Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
doxylamine increases effects of letibotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Drugs with anticholinergic effects may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
levetiracetam and doxylamine both increase sedation. Use Caution/Monitor.
levocetirizine and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and levorphanol both increase sedation. Use Caution/Monitor.
doxylamine and lofepramine both increase sedation. Use Caution/Monitor.
doxylamine and lofexidine both increase sedation. Use Caution/Monitor.
loprazolam and doxylamine both increase sedation. Use Caution/Monitor.
loratadine and doxylamine both increase sedation. Use Caution/Monitor.
lorazepam and doxylamine both increase sedation. Use Caution/Monitor.
lormetazepam and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and loxapine both increase sedation. Use Caution/Monitor.
doxylamine and loxapine inhaled both increase sedation. Use Caution/Monitor.
lumateperone and doxylamine both increase sedation. Use Caution/Monitor.
lurasidone, doxylamine.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.
doxylamine and maprotiline both increase sedation. Use Caution/Monitor.
doxylamine and marijuana both increase sedation. Use Caution/Monitor.
doxylamine and melatonin both increase sedation. Use Caution/Monitor.
doxylamine and meperidine both increase sedation. Use Caution/Monitor.
doxylamine and meprobamate both increase sedation. Use Caution/Monitor.
doxylamine and metaxalone both increase sedation. Use Caution/Monitor.
doxylamine and methadone both increase sedation. Use Caution/Monitor.
doxylamine and methocarbamol both increase sedation. Use Caution/Monitor.
methohexital and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
midazolam and doxylamine both increase sedation. Use Caution/Monitor.
midazolam intranasal, doxylamine.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
doxylamine and mirtazapine both increase sedation. Use Caution/Monitor.
doxylamine and morphine both increase sedation. Use Caution/Monitor.
doxylamine and motherwort both increase sedation. Use Caution/Monitor.
doxylamine and moxonidine both increase sedation. Use Caution/Monitor.
doxylamine and nabilone both increase sedation. Use Caution/Monitor.
doxylamine and nalbuphine both increase sedation. Use Caution/Monitor.
doxylamine and nortriptyline both increase sedation. Use Caution/Monitor.
doxylamine and olanzapine both increase sedation. Use Caution/Monitor.
doxylamine, olanzapine/samidorphan.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of diazepam, alcohol, or other CNS acting drugs may potentiate orthostatic hypotension observed with olanzapine. Additive sedation may also occur.
oliceridine, doxylamine.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
doxylamine increases effects of onabotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Drugs with anticholinergic effects may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
doxylamine and opium tincture both increase sedation. Use Caution/Monitor.
doxylamine and orphenadrine both increase sedation. Use Caution/Monitor.
oxazepam and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and oxycodone both increase sedation. Use Caution/Monitor.
doxylamine and oxymorphone both increase sedation. Use Caution/Monitor.
doxylamine and paliperidone both increase sedation. Use Caution/Monitor.
doxylamine and papaveretum both increase sedation. Use Caution/Monitor.
doxylamine and papaverine both increase sedation. Use Caution/Monitor.
passion flower increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
doxylamine and pentazocine both increase sedation. Use Caution/Monitor.
pentobarbital and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and perphenazine both increase sedation. Use Caution/Monitor.
phenelzine increases effects of doxylamine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Coadministration of phenelzine and antihistamines may result in additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .
phenobarbital and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
doxylamine and pholcodine both increase sedation. Use Caution/Monitor.
doxylamine and pimozide both increase sedation. Use Caution/Monitor.
doxylamine increases effects of prabotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Drugs with anticholinergic effects may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
pregabalin, doxylamine.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
primidone and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and prochlorperazine both increase sedation. Use Caution/Monitor.
promethazine and doxylamine both increase sedation. Use Caution/Monitor.
propofol and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
doxylamine and protriptyline both increase sedation. Use Caution/Monitor.
quazepam and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and quetiapine both increase sedation. Use Caution/Monitor.
doxylamine and ramelteon both increase sedation. Use Caution/Monitor.
remimazolam, doxylamine.Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
doxylamine increases effects of rimabotulinumtoxinB by pharmacodynamic synergism. Use Caution/Monitor. Drugs with anticholinergic effects may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects.
doxylamine and risperidone both increase sedation. Use Caution/Monitor.
doxylamine and scullcap both increase sedation. Use Caution/Monitor.
secobarbital and doxylamine both increase sedation. Use Caution/Monitor.
sevoflurane and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and shepherd's purse both increase sedation. Use Caution/Monitor.
stiripentol, doxylamine.Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
doxylamine and sufentanil both increase sedation. Use Caution/Monitor.
doxylamine and tapentadol both increase sedation. Use Caution/Monitor.
temazepam and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and thioridazine both increase sedation. Use Caution/Monitor.
doxylamine and thiothixene both increase sedation. Use Caution/Monitor.
doxylamine and topiramate both increase sedation. Modify Therapy/Monitor Closely.
doxylamine and tramadol both increase sedation. Use Caution/Monitor.
doxylamine and trazodone both increase sedation. Use Caution/Monitor.
triazolam and doxylamine both increase sedation. Use Caution/Monitor.
doxylamine and triclofos both increase sedation. Use Caution/Monitor.
doxylamine and trifluoperazine both increase sedation. Use Caution/Monitor.
doxylamine and trimipramine both increase sedation. Use Caution/Monitor.
triprolidine and doxylamine both increase sedation. Use Caution/Monitor.
valerian increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.
doxylamine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
doxylamine and ziconotide both increase sedation. Use Caution/Monitor.
doxylamine and ziprasidone both increase sedation. Use Caution/Monitor.
doxylamine and zotepine both increase sedation. Use Caution/Monitor.
